Drew Barrymore really wanted Bon Jovi's "Living on a Prayer" in a flashback scene. However, the rights to the song were too expensive, so Barrymore called Jon Bon Jovi told him how much she loved the song and how important it was to her that it be in the scene, and Bon Jovi found a loophole to enable them to use the song.

Bill Murray did not want to reprise his role as Bosley because he refused to work with Director McG again. Murray also had problems with Lucy Liu on the first film, but publicly insisted that Liu was not the reason for his departure.

Bruce Willis, who is an advocate for adoption, has a cameo in the film. He asked Drew Barrymore, Cameron Diaz, and Lucy Liu for a favor for his cameo, that they do a PSA for adoption. They gladly did it.

Pete's high school reunion is for Rydell High School, the same school from Grease (1978) and Grease 2 (1982).

All of the Irish characters (including the henchmen) are either Scottish, English, or American. None of them actually come from Ireland. This was referenced in deleted scene where Bernie Mac complains that the Irish accent he is putting on sounds just as real as theirs.

Drew Barrymore is a fervent believer in gun control. That's why none of the Angels are seen using guns in this picture.

For the "U Can't Touch This" dance scene, Drew Barrymore and Lucy Liu wore heels in order to fit in the same frame as Cameron Diaz, who is barefoot.

A new version of David Bowie's "Rebel Rebel" was recorded for Dylan's appearance as a wrestling star. Her make-up mimics that of Bowie's character Aladdin Sane.

For the scene where Natalie (Cameron Diaz) is distracting the surfer at the beach and Alex (Lucy Liu) and Dylan (Drew Barrymore) are underneath his GTO collecting clues, the car had to be put on jacks because the actresses couldn't fit underneath of it.

Jamie Foxx was originally in talks to play Jimmy Bosley.

The mansion where the convent is located can be recognized as the Playboy Mansion. This is where the young boys looking at the Playboy Magazine comes from.

During the motocross scene, four famous riders have a cameo: Ricky Carmichael, Jeremy McGrath, Chris Gosselaar, and Carey Hart.

When O'Grady gets released from prison, the picture on his wall of Dylan is a still of Drew Barrymore from the Aniołki Charliego (2000) backstory montage when she was smoking in the bathroom with a cast on her arm.

John Forsythe 's final film.

Courtney Love was offered the role of Madison Lee, but turned it down.

In the weeks prior to the film's release, a series of short animated adventures featuring the voice of John Forsythe as Charlie were produced and distributed over the Internet. Charlie's Angels: Animated Adventures (2003) expand upon events shown at the start of the film.

Tyler Hoechlin auditioned for the part of Max.

The address on the envelope that Pete opens at the beginning of the film gives Pete and Natalie's address as 2028 The Strand, Hermosa Beach, California, which is a valid address on the beach.

A photograph of Bill Murray is visible in Mama Bosley's home. Murray appeared as Bosley in Aniołki Charliego (2000).

The working title of the film was "Halo".

Second movie where Carrie Fisher plays a nun. The first being Jay i Cichy Bob kontratakują (2001).

Carrie Fisher's portrayal of the Mother Superior is an homage to the scene in The Blues Brothers (1980) where the Mother Superior played by Kathleen Freeman asks Jake and Elwood to move their desks closer - which is done by staying in their desk chairs and scooting them forward as the Angels do in this film; and she also used a long wooden pointer to display her disapproval at unacceptable behavior as the Mother Superior does in this film. Carrie Fisher appeared in The Blues Brothers (1980) as Jake's homicidal ex-fiancé.

The angels dance the "Pink Panther" theme at one point. The Brazilian title for the "Charlie's Angels" franchise (both films and the television series) is "As Panteras" ("The Panthers").

In the warehouse fight scene, the song Firestarter by The Prodigy is playing in the background. Later, after the Angels escape the warehouse, Dylan lights a liquid fuel gun handled by Alex, using her "trusty lighter" featured in the first movie, where Dylan was tied to a chair. Drew Barrymore, who plays Dylan, starred in Firestarter (1984), a movie about a little girl with pyrokinetic abilities (the ability to start fires with her mind).

When Justin Theroux emerges from the warehouse fire, the theme song from Przylądek strachu (1991) is played.

Andrew Wilson, brother of Luke Wilson (Pete), makes a brief appearance as a police officer.

This is one of two movies in which Cameron Diaz cuts a bottle open with a knife. The other is Co się zdarzyło w Las Vegas (2008).

In the M.C. Hammer dance scene and the hot dog seller scene, Dylan has the word Kodachrome written in black pen on her left forearm. Kodachrome is the title of a 1973 song written by Paul Simon. This movie was shot on Kodak film stock.

The car that Natalie (Cameron Diaz) drives while following Carter (Robert Patrick) is a 1961 Ferrari 250 GT California, made famous by Ferris Bueller's Day Off (1986). That film was unable to rent the actual car and created a replica to use for filming, whereas this film used the actual car, valued at over one million dollars.

Joan Cusack were considered for the role of Madison Lee.

Pink and The Pussycat Dolls made cameo appearances in this movie. The Pussycat Dolls also made an appearance in Pink's music video for her song "Trouble".

The scene in which Natalie Cook (Cameron Diaz) dances in a giant Champagne glass is a parody of the Glass Show made famous by burlesque dancer Dita Von Teese, in which the latter performs in a life sized martini glass.

Jeff Daniels were considered for the role of Ray Carter.

Tom Hanks were considered for the role of Seamus O'Grady.

This was a monumental comedown for Demi Moore, who just seven years earlier had been the highest-paid actress in movies. The role of Madison Lee was little more than an extended cameo; it was only a "comeback" in the sense that Moore hadn't appeared onscreen since Wysniona namietnosc (2000), and nothing before that since Przejrzec Harry'ego (1997) and G.I. Jane (1997).

Will Smith were considered for the role of Jimmy Bosley.

One scene shows the Angels masquerading as welders while the song "What A Feeling" from the movie Flashdance (1983) plays on the soundtrack; Drew Barrymore previously co-starred in the movie Pobozne zyczenie (1997) with Jennifer Beals, who had starred as a welder/dancer in Flashdance (1983).

The Angels say, "Do a little dance. Make a little love. Get down tonight", a reference to the KC & The Sunshine Band song, "Get Down Tonight".

It is unclear and not explained in the film why Jimmy Bosley replaced John Bosley and why John Bosley was absent in this film.

In the first movie, Alex was believed to be a bikini waxer, while in the second movie, she is in a scene where Natalie was in a bikini, and looking for a waxer of surfboards.

A third "Charlie's Angels" film never happened.

Jaclyn Smith: Reprises her television series role as Kelly Garrett. Smith was the only actress to appear in every episode of the original show.

Carrie Fisher: As Mother Superior.

Pink, Carey Hart: The singer and her "motocrosser" boyfriend (later husband) are talking when Natalie walks up.

Melissa McCarthy: She is in the background when the girls arrive as crime scene investigators, she had a small role in Aniołki Charliego (2000) as Doris the receptionist at Red Star.

Bruce Willis: As William Rose Bailey. The name is a reference to Guns N' Roses singer W. Axl Rose, whose real name was William Bruce Bailey until he was seventeen.

Carmit Bachar: The Pussycat Dolls background dancer performs in the sailors' club.

Eve: As a potential Angel wannabe. This is a possible reference to Shari Belafonte almost beating out Tanya Roberts for the part of Julie Rogers, when Shelley Hack was fired from Aniołki Charliego (1976) in 1980.

Joseph G. Aulisi: The doctor in the flashbacks with Anthony the Thin Boy.

Bruce Willis' Senator character is shot in the head by Madison, Demi Moore's character, or perhaps someone working for her, as it is never made clear who pulled the trigger. In real-life, the two had just recently gotten divorced.

When the Angels are all shot by Madison, the formation they make on the ground where they lay is the same as the Charlie's Angels symbol (but without the guns, obviously).

The "fallen Angel" storyline, featuring Madison Lee, was originally intended to be the basis of a third Charlie's Angels film.

Body count: twenty years (seventeen more then the first movie).

John Forsythe voices the character of Charles Townsend in this film, as he did in the first, as well as the television series. One of Madison Lee's (Demi Moore's) thugs was played by Charles Townsend.

In the scene where Madison Lee (Demi Moore) is walking out of Charlie Townsend's office, behind her on the walls are photographs of former Angels. Included among the photos are Tanya Roberts, Janet Jackson, Jodie Foster, Christie Brinkley, and Heather Locklear.

When Madison and Natalie are on the beach talking, Madison is wearing a black bikini and Natalie is wearing a white bikini which foreshadows that Madison is the "bad guy" and has gone dark and represents that she is no longer an Angel, while Natalie is loyal to Charlie and is still considered to be an Angel that is innocent; hence the white.

Demi Moore and Robert Patrick appeared in Striptease (1996).

Towards the end of the movie, Bosley uses a pole to swat a bomb thrown by Madison out of the air like a baseball. Bernie Mac starred in the baseball movie Mr. 3000 (2004).

The scene which Natalie and Madison meet on the beach which Natalie wears a white bikini and Madison wears a black bikini hints at Madison being the villain and the mastermind behind the theft of the H.A.L.O. rings.

Like GoldenEye (1995). Mission: Impossible (1996) and Mission: Impossible II (2000), Dylan, Alex, and Natalie discover Madison Lee (a former Angel) has gone renegade and is behind the HALO theft.