| Episode credited cast: |
 | David Letterman | - | Himself - Host |
 | Noel Gallagher's High Flying Birds | - | Themselves - Musical Guests |
 | Rick Perry | - | Himself - Top Ten List Presenter |
 | Paul Shaffer | - | Himself - Musical Director |
| Rest of cast listed alphabetically: |
| Herman Cain | - | Himself (archive footage) |
 | Bill Clinton | - | Himself - 1992 Convention Speech (archive footage) |
 | Noel Gallagher | - | Himself (as Noel Gallagher's High Flying Birds) |
 | Katie Holmes | - | Herself - Guest |
| Alan Kalter | - | Himself - Announcer |
 | Steve Martin | - | Himself - Guest |
 | Russell Pritchard | - | Himself (as Noel Gallagher's High Flying Birds) |
 | Ronald Reagan | - | Himself - 1980 Convention Speech (archive footage) |
| Mike Rowe | - | Himself (as Noel Gallagher's High Flying Birds) |
| Tim Smith | - | Himself (as Noel Gallagher's High Flying Birds) |
| Jeremy Stacey | - | Himself (as Noel Gallagher's High Flying Birds) |
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