| Episode credited cast: |
 | David Letterman | - | Himself - Host |
 | Tom Hanks | - | Himself - Guest |
 | Spoon | - | Themselves - Musical Guest |
 | Paul Shaffer | - | Himself - Musical Director |
| Rest of cast listed alphabetically: |
 | Biff Henderson | - | Himself - Visiting Set of 'Cop Out' |
| Steve Holcomb | - | Himself - Top Ten List Presenter |
| Steve Mesler | - | Himself - Top Ten List Presenter |
 | Tracy Morgan | - | Himself - Interviewed by Biff Henderson |
| Justin Olsen | - | Himself - Top Ten List Presenter |
 | Kevin Smith | - | Himself - Guest |
| Curt Tomasevicz | - | Himself - Top Ten List Presenter |
 | Bruce Willis | - | Himself - Interviewee |
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