| Episode credited cast: |
 | Mike Greenberg | - | Himself - Co-Host |
 | Mike Golic | - | Himself - Co-Host |
| Rest of cast listed alphabetically: |
| Kristen Balboni | - | Herself - Researcher, Mike & Mike |
 | Barbara Bush | - | Herself (archive footage) |
 | George Bush | - | Himself (archive footage) |
| Liam Chapman | - | Himself - Producer, Mike & Mike |
 | Mark Cuban | - | Himself - Owner, Dallas Mavericks (archive sound) |
| Seth Greenberg | - | Himself - ESPN College Basketball Analyst |
| Ron Jaworski | - | Himself - ESPN NFL Analyst (archive sound) |
| Johnny Manziel | - | Himself - Former Texas A&M University Quarterback (archive footage) |
| Todd McShay | - | Himself - ESPN NFL Draft Insider (voice) |
| Archie Miller | - | Himself - University of Dayton Men's Basketball Coach (voice) |
| Brendan Peregrin | - | Himself - Segment "Love It or Shove It" (as Bubba) |
| Digger Phelps | - | Himself - Segment "Three's Company" |
 | Darius Rucker | - | Himself - Cohost, Final Two Hours |
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