| Episode credited cast: |
 | Jorge Sedano | - | Himself - Substitute Co-Host |
| Mike Golic | - | Himself - Co-Host |
| Rest of cast listed alphabetically: |
| Kristen Balboni | - | Herself - Researcher, Mike & Mike (as Balbiz) |
 | Anthony Bosch | - | Himself (archive footage) |
 | Tom Brady | - | Himself - New England Patriots Quarterback (archive footage) |
 | Drew Brees | - | Himself - New Orleans Saints Quarterback (archive footage) |
 | Cris Carter | - | Himself - ESPN NFL Analyst |
| Liam Chapman | - | Himself - Producer. Mike & Mike |
 | Mike Ditka | - | Himself - ESPN NFL Analyst (voice) |
 | Mike Greenberg | - | Himself - ESPN Radio (voice) |
| Ron Jaworski | - | Himself - ESPN NFL Analyst |
 | Colin Kaepernick | - | Himself - San Francisco 49ers Quarterback (archive footage) |
| Curt Kaplan | - | Himself - Associate Producer, Mike & Mike (voice) |
| Andrew Luck | - | Himself - Indianapolis Colts Quarterback (archive footage) |
 | Peyton Manning | - | Himself - Denver Broncos Quarterback (archive footage) |
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