| Episode credited cast: |
 | Ben Shephard | - | Himself - Presenter |
 | Kate Garraway | - | Herself - Presenter |
| Rest of cast listed alphabetically: |
 | Richard Arnold | - | Himself - Entertainment Editor |
 | Natasha Carter | - | Herself - Granada North West Newsreader |
 | Nick Dixon | - | Himself - Correspondent |
 | Juliet Dunlop | - | Herself - Correspondent |
 | Peter-Marc Fortune | - | Himself - President of the Paediatric Intensive Care Society (as Dr Peter-Marc Fortune) |
 | Courtney Hadwin | - | Herself - The Voice Kids Finalist |
 | Charlotte Hawkins | - | Herself - Presenter |
 | Lorraine Kelly | - | Herself - Lorraine Presenter |
 | Jon Mitchell | - | Himself - Granada North West Weather Forecaster |
| Sarah Newton | - | Herself - Home Office Minister (as Sarah Newton MP) |
 | Andi Peters | - | Himself - Competition Presenter |
 | Amber Rudd | - | Herself - Home Secretary (as Amber Rudd MP) |
| Connie Yates | - | Herself - Charlie Gard's Mother (archive footage) |
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