The Dan Patrick Show watch online HD

Patrick takes pride in that he does not allow guests to come on the show if it is agreed off-air he can only ask certain questions on-air.

Current regular guests include reporters, broadcasters, and former professional coaches and athletes (most whom are current broadcasters) working for a variety of media outlets, including Sports Illustrated, Yahoo! Sports, network and cable stations and reporters from local media sources covering the beat involving a team, player or league in the news at the time.

There have been guests who have cancelled appearances due to Patrick's desire for candor. If he disagrees with a guests comments or actions, he does not shy away from letting the guest and audience know he has a different opinion.

Patrick is known for his wry, irreverent interviews, often asking humorous hypothetical questions and occasionally making bets with his guests.

In January 2006, Patrick made a bet with Arizona Cardinals quarterback Kurt Warner, where if Warner got the Cardinals to the Super Bowl by 2008, then Patrick would personally campaign for Warner to be inducted into the Pro Football Hall of Fame (Warner took Arizona to the Super Bowl in the 2008 NFL season, and would later be inducted into the Hall of Fame in 2017).

The Danettes are generally encouraged to speak honestly and share their actual opinions, with Patrick often carrying on with them in a conversational manner. Patrick has acknowledged that he was influenced by Howard Stern when incorporating the members of his staff into the on-air aspects of the show.

Guests typically appear when the sport they are involved with is in-season, but may also come on before the release of a movie or music album or when the guest's name is mentioned in much recent news, such as an off-season trade or violation of the law.

The overwhelming majority of guests, however, are involved with sports, whether current or former athletes, coaches, commissioners or agents. Less often, guests who are not affiliated with sports will come on the show, although it is common for Patrick to ask at least one sports related question.