| Episode credited cast: |
 | Marcus du Sautoy | - | Himself - Presenter (as Prof Marcus du Sautoy) |
| Rest of cast listed alphabetically: |
 | Ognjen Amidzic | - | Himself - Amidzic Consulting (as Dr Ognjen Amidzic) |
| Arthur Benjamin | - | Himself - Harvey Mudd College (as Prof Arthur Benjamin) |
| Manuel Casanova | - | Himself - University of Louisville (as Prof Manuel Casanova) |
| Stuart Conquest | - | Himself |
| Justin Halberda | - | Himself - Johns Hopkins University (as Prof Justin Halberda) |
| Annette Karmiloff-Smith | - | Herself - Birkbeck University of London (as Prof Annette Karmiloff-Smith) |
| Mark Lythgoe | - | Himself - University College London (as Dr Mark Lythgoe) |
| Tommy McHugh | - | Himself |
| Elly Nedivi | - | Herself - Massachusetts Institute of Technology (as Prof Elly Nedivi) |
| Adam Ockelford | - | Himself - Roehampton University (as Prof Adam Ockelford) |
| Walter Paulus | - | Himself - University of Göttingen (as Prof Walter Paulus) |
| Philip Shaw | - | Himself - National Institute of Health (as Prof Philip Shaw) |
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