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A professor/inmate in a psychiatric ward may be influencing other men to kill ritualistically. Though Doggett sees it as pure manipulation, Reyes can't help but suspect none else but the devil himself possessing the professor's body.

Doggett suggests to Reyes the killer might use human flesh to fertilise his garden - an in-joke referencing the movie The Last Supper (1995), which starred Annabeth Gish.

The first time Satan is overtly suggested as the antagonist. This is also the first time Doggett and Reyes confront a demonic entity in an X-File; Scully has been in four satanic X-Files in the past (The X Files: Die Hand Die Verletzt (1995), The X Files: All Souls (1998), The X Files: Terms of Endearment (1999), and The X Files: Orison (2000)).

Mr. Kobold is named directly after 'kobold', the German word for a goblin or evil spirit

Actor James Remar says The X-Files saved his life. He had been in New York City that summer, riding the Ladder Company 3 truck with friend Patrick Brown. The show induced him to take the role and he joined the cast and crew days before 9/11 happened. Ladder Company 3 suffered some of the heaviest casualties that day, including Brown.

The Guard outside Dr. Kobolds room is reading an American Ronin magazine previously seen in the episode Pusher.