| Episode cast overview, first billed only: |
 | Roger Johnson | - | Himself - Presenter |
 | Nina Warhurst | - | Herself - Presenter |
| Casey Musgrave | - | Himself - Friend |
| David Gillard | - | Himself - Local Resident |
| Dave Guest | - | Himself - Reporter |
| Beckie Ramsay | - | Herself - Dylan's Mother |
| Jon Aspinall | - | Himself - Greater Manchester Fire & Rescue Service |
| Hugh Bearn | - | Himself (voice) (as The Reverend Hugh Bearn) |
| Charlotte Hardy | - | Herself - Olivia's Mother (as Charlotte Campbell) |
| Louise Tipping | - | Herself - Principal, Winstanley College |
 | Andy Burnham | - | Himself - Mayor of Greater Manchester |
 | Peter O'Reilly | - | Himself - Greater Manchester Fire & Rescue Service |
| Damien Weber | - | Himself - Chair, Centre for Proton Therapy (as Professor Damien Weber) |
| Ute Liebsch | - | Herself - Patient, Paul Scherrer Institute |
| Tony Lomax | - | Himself - Head of Medical Physics (as Professor Tony Lomax) |
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