| Episode cast overview, first billed only: |
 | Swoosie Kurtz | - | Alex Reed Barker |
 | Patricia Kalember | - | Georgie Reed Whitsig (credit only) |
 | Julianne Phillips | - | Francesca 'Frankie' Reed Margolis |
 | Sela Ward | - | Teddy Reed |
 | Elizabeth Hoffman | - | Beatrice 'Bea' Reed Ventnor (credit only) |
 | Garrett M. Brown | - | John Whitsig |
 | Ed Marinaro | - | Mitch Margolis |
 | Heather McAdam | - | Catherine 'Cat' Margolis |
 | Robert Klein | - | Albert 'Big Al' Barker |
 | Jo Anderson | - | Dr. Charlotte 'Charley' Bennett |
 | Isabella Hofmann | - | Abby Malker |
 | Eamonn Roche | - | Jordan |
 | Peter White | - | Dr. Thomas Reed |
| Jill Novick | - | Teenage Teddy |
| Sharon Martin | - | Teenage Alex |
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