| Episode credited cast: |
 | Bill O'Reilly | - | Himself - Host |
 | Karl Rove | - | Himself |
| Howard Wolfson | - | Himself - Fox News Contributor |
| Frank Luntz | - | Himself - Pollster (as Frank Luntz Ph.D.) |
 | Tim Pawlenty | - | Himself - Minnesota Governor (as Gov. Tim Pawlenty) |
 | Megyn Kelly | - | Herself (segment "Is It Legal?") |
| Lis Wiehl | - | Herself (segment "Is it Legal?") (as Lisl Weil) |
 | Newt Gingrich | - | Himself |
| Rest of cast listed alphabetically: |
 | Joe Biden | - | Himself (archive footage) (as Sen. Joe Biden) |
 | Chelsea Clinton | - | Herself (archive footage) |
 | Hillary Clinton | - | Herself (archive footage) (as Hillary Rodham Clinton) |
 | Sean 'Diddy' Combs | - | Himself - 'Pinhead' (segment "Pinheads & Patriots") (archive footage) (as P Diddy) |
 | Al Franken | - | Himself (archive footage) |
 | Jerry Lewis | - | Himself - (segment "Pinheads & Patriots") (archive footage) |
| Cindy McCain | - | Herself (archive footage) |
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