| Episode credited cast: |
 | Bill O'Reilly | - | Himself - Host |
| Rest of cast listed alphabetically: |
 | Lucille Ball | - | Lucy Ricardo (segment "Watters' World") (archive footage) |
 | Brooke Burke | - | Herself (segment "Watters' World") (as Brooke Burke-Charvet) |
 | Nicholas Colasanto | - | Coach (segment "Watters' World") (archive footage) |
 | Rodney Dangerfield | - | Himself (segment "Watter's World") (archive footage) |
 | Robert De Niro | - | Himself (segment "Watter's World") |
 | Jacques DeGraff | - | Himself (as Rev. Jacques DeGraff) |
 | Josh Gad | - | Himself (segment "Watters' World") |
 | Jorge Garcia | - | Himself (segment "Watters' World") |
 | Bill Hader | - | Himself (segment "Watters' World") |
| Mary Katharine Ham | - | Herself - Editor-in-Chief, HotAir.com |
 | Cheryl Hines | - | Herself (segment "Watter's World") |
| Brit Hume | - | Himself - Fox News Senior Political Analyst |
| Robert Jeffress | - | Himself (as Pastor Robert Jeffress) |
 | Sally Kellerman | - | Herself (segment "Watter's World") (archive footage) |
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