| Credited cast: |
 | 50 Cent | - | Himself |
| Rest of cast listed alphabetically: |
 | 25 Cent | - | Himself (segment "Wanksta") |
 | La La Anthony | - | Herself (as LaLa Vazquez) |
 | Philip G. Atwell | - | Himself (segment "Behind the Scenes of In Da Club") |
 | Lloyd Banks | - | Himself |
| Bizarre | - | Himself (segment "The Detroit Show") |
| Young Buck | - | Himself (segment "The Detroit Show") |
| D12 | - | Themselves (segment "The Detroit Show") |
 | Dr. Dre | - | Himself (segment "In Da Club") |
 | Eminem | - | Himself (segments "The Detroit Show" and "In Da Club") |
 | Game | - | Himself (segment "In Da Club") (as The Game) |
| DJ Green Lantern | - | Himself |
| Guru | - | Himself (segment "The New Breed") (as The Guru) |
| Kuniva | - | Himself (segment "The Detroit Show") |
 | Lil' Maxso | - | Himself (segment "Wanksta") |
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