| Episode credited cast: |
 | David Letterman | - | Himself - Host |
 | Denis Leary | - | Himself - Guest |
 | John Mayer | - | Himself - Musical Guest |
 | Chris Botti | - | Himself - Musical Support |
 | Dorothy Mengering | - | Herself - Annual Thanksgiving Pie Baker |
 | Paul Shaffer | - | Himself - Musical Director |
| Rest of cast listed alphabetically: |
 | Joe Grossman | - | Himself - Celebrates Thanksgiving |
| Biff Henderson | - | Himself - Celebrates Thanksgiving |
| Harry Joseph Letterman | - | Himself - Celebrates Thanksgiving |
| Victoria Lilly | - | Herself |
| Tony Mendez | - | Himself - Cue Card Boy |
| Justin Stangel | - | Himself - Celebrates Thanksgiving |
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