| Episode cast overview, first billed only: |
 | Christopher Timothy | - | Dr. Brendan 'Mac' McGuire |
 | Mark Frost | - | Dr. Steve Rawlings (credit only) |
 | Corrinne Wicks | - | Dr. Helen Thompson |
 | Akbar Kurtha | - | Dr. Rana Mistry (credit only) |
| Jacqueline Leonard | - | Dr. Caroline Powers |
 | Maggie Cronin | - | Kate McGuire |
| Yvonne Brewster | - | Ruth Harding (credit only) |
| Sarah Manners | - | Joanna Helm |
 | Steven Brand | - | Chris Rawlings |
| Mark Adams | - | Phil Thompson |
 | Vinette Robinson | - | Cath Bickerstaff |
| Nicholas Moss | - | Trevor |
| Colin Wells | - | Eddie Melia |
| Richard Waters | - | D.I. Matt Brandon |
| Jon Carver | - | Custody Sergeant |
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