| Episode credited cast: |
 | Ike the Cat | - | Himself |
| Mike the Cat | - | Himself |
| Vanessa the Cat | - | Herself |
| Diane DiGiacomo | - | Herself - ASPCA Special Agent for Humane Law Enforcement |
| Mandy the Dog | - | Herself |
| Yolanda the Dog | - | Herself |
| Annemarie Lucas | - | Herself - ASPCA Supervisory Special Investigator for Humane Law Enforcement |
| Mark MacDonald | - | Himself - ASPCA Special Investigator for Humane Law Enforcement |
 | Michael Madsen | - | Narrator (voice) |
| Karen Miller | - | Herself |
| Meghan Rogers | - | Herself |
| Joann Sandano | - | Herself - ASPCA Special Agent for Humane Law Enforcement |
| Michael Tietje | - | Himself - ASPCA Special Agent for Humane Law Enforcement |
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