| Episode credited cast: |
 | Kevin Fong | - | Himself - Presenter (as Dr Kevin Fong) |
| Rest of cast listed alphabetically: |
| John Elefteriades | - | Himself - Yale New Haven Hospital (as Dr John Elefteriades) |
| Asif Hasan | - | Himself - Freeman Hospital (as Mr Asif Hasan) |
| Douglas Horstmanshof | - | Himself - INTEGRIS Advanced Cardiac Care (as Dr Douglas Horstmanshof) |
| Paul A. Iaizzo | - | Himself - University of Minnesota (as Prof Paul A. Iaizzo) |
| Richard Kirk | - | Himself - Freeman Hospital (as Dr Richard Kirk) |
| James Long | - | Himself - INTEGRIS Advanced Cardiac Care (as Dr James Long) |
| Anthony Mathur | - | Himself - Barts and the London NHS Trust (as Prof Anthony Mathur) |
| Reza Razavi | - | Himself - King's College London (as Prof Reza Razavi) |
| Peter Reed | - | Himself |
| Len Shapiro | - | Himself - Papworth Hospital (as Dr Len Shapiro) |
| Nic Smith | - | Himself - King's College London (as Prof Nic Smith) |
| Doris A. Taylor | - | Herself - University of Minnesota (as Dr Doris A. Taylor) |
| Andrew Triggs Hodge | - | Himself |
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