| Episode credited cast: |
 | Christopher Timothy | - | Dr. Brendan 'Mac' McGuire (credit only) |
 | Maggie Cronin | - | Kate McGuire |
 | Corrinne Wicks | - | Dr. Helen Thompson (credit only) |
 | Tom Butcher | - | Dr. Marc Eliot |
 | Ariyon Bakare | - | Dr. Ben Kwarme |
| Natalie J. Robb | - | Dr. Jude Carlyle |
| Laurence Penry-Jones | - | Dr. Oliver Berg (credit only) |
 | Stirling Gallacher | - | Dr. Georgina Woodson (credit only) |
 | Eva Fontaine | - | Faith Walker |
| Ela Kay | - | Carolina Shaw (credit only) |
 | Diane Keen | - | Julia Parsons (credit only) |
| Rest of cast listed alphabetically: |
 | Patricia Brake | - | Judge Margaret Harrison |
 | Richard Cotton | - | Forensic Surgeon (as Richard Wills-Cotton) |
| David Firth | - | David Sheldon |
| Sean Gleeson | - | Ronnie Woodson |
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